Molecular Formula | C24H25N8O10PS4 |
Molar Mass | 744.72 |
Storage Condition | 2-8℃ |
In vivo study | Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% f T>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log 10 kill. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log 10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log 10 CFU. |
Biological activity | Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin that is active against Gram-positive pathogens (including methicillin-resistant Staphylococcus aureus (MRSA)). |